The establishment is run by a board of directors composed of six members.
Five of them are appointed and dismissed by the Grand Duke.
Three directors represent the State directly and are nominated by the Minister of Health, the Minister of Social Security and the Ministers of Finance.
Two directors are nominated by the Government in Council from among personalities from the private sector, chosen for their competence in business administration.
The management of the establishment is entrusted to a manager appointed by the board of directors subject to approval by the Government in Council.
The manager is bound to the centre by a private law contract.
The manager attends the meetings of the board of directors in an advisory capacity.
He implements the decisions of the Board of Directors and is responsible for the day-to-day management of the Centre. He is vested with powers to attend all matters not specifically devolved to the Board of Directors.
He represents the centre in all public and private acts.